I am interested in how populations diverge and adapt to the environments they encounter. To identify and characterize specific genes and pathways that underlie adaptive change, I combine statistical and genomic approaches with knowledge from organismal and ecological studies. My work utilizes a range of technological and analytical methods and involves collaborations with researchers who climb Mexican volcanoes and explore Caribbean Islands for exotic species who are specially adapted to their extreme environments. By correlating genetic changes to phenotypic outcomes using population genomics, I hope to link genomic changes to sources of selection.
Kelley, J.L., Passow, C., Plath, M., Rodrigues, L.A., Yee,
M.C., and M. Tobler. (2012) Genomic resources for a model in
adaptation and speciation research: characterization of the
Poecilia mexicana transcriptome. BMC Genomics. 13:652
Teets, N.M, Peyton, J.T., Colinet, H., Renault, D., Kelley, J.L., Kawarasaki , Y., Lee Jr., R.E., Denlinger, D.L. (2012) Gene expression changes governing extreme dehydration tolerance in an Antarctic insect. Proceedings of the National Academy of Sciences. 109: 20744-20749
Kelley, J.L. (2012) Biased estimates of dating selection pressures in recent human evolution. Frontiers in Evolutionary and Population Genetics. 3:165
Kelley, J.L., Yee, M.C., Lee, C., Levandowsky, E., Shah, M., Harkins, T., Earley, R.L., and C.D. Bustamante. (2012) The possibility of de novo assembly of a genome and population genomics of the mangrove rivulus Kryptolebias marmoratus. Integrative and Comparative Biology. 52:737-42
Hernandez, R.D., Kelley, J.L., Elyashiv, E., Melton, S.C., Auton, A., McVean, G., Sella, G., Przeworski, M., and 1000 Genomes Project Consortium. (2011) Classic selective sweeps were rare in recent human evolution. Science 331: 920-24.
1000 Genomes Project Consortium, Abecasis G.R., Altshuler D.L., Auton A., Brooks L.D., Durbin R.M., Gibbs R.A., Hurles M.E., McVean G.A. (2010) A map of human genome variation from population-scale sequencing. Nature 467:1061-73.
Kelley, J.L., Aagaard, J., MacCoss, M. and W. Swanson. (2010) Functional diversification and evolution of antifreeze proteins in the Antarctic fish Lycodichthys dearborni. Journal of Molecular Evolution 71:111-118.