My laboratory is studying the fascinating group of protozoan parasites of invertebrates called gregarines in the phylum Apicomplexa, which includes the malaria parasites. Of the three subgroups of gregarines, eugregarines are the most species-rich with the widest range of host species. Eugregarines are commonly found in their hosts, that is, many invertebrate species are naturally infected, a great majority of individuals in the population are infected, and many individuals in the population are highly infected.
They appear to have little or no negative impact on their host thus explaining their wide prevalence in a number of hosts in which they have been studied. Despite this prevalence, they are understudied.
Thus my laboratory is studying their ultrastructure, development, evolution and impact on their host.
Lord, J.C. & Omoto, C.K. 2012. Eugregarines reduce susceptibility of the hide beetle, Dermestes maculatus, to apicomplexan pathogens and retard larval development. J. of Invert. Path. 111:186-188.
Toso, M. A. and C.K. Omoto. 2007. Gregarina niphandrodes may lack both a plastid genome and organelle. J. Euk. Microbiol. 54:66-72
Toso, M. A. and C.K. Omoto. 2007. Ultrastructure of Gregarina niphandrodes nucleus through stages from unassociated trophozoites to gamonts in syzygy and the syzygy junction. J Parasitology 93(3): 479-484
Yesenia Rodriguez, C.K. Omoto, R. Gomulkiewicz. Individual and Population Effects of Eugregarine, Gregarina niphandrodes (Eugregarinida: Gregarinidae), on Tenebrio molitor (Coleoptera: Tenebrionidae) Environmental Entomology 36 (4):681-688.
Kuriyama, R., C. Besse, M. Geze, C.K. Omoto, J. Schrevel. 2005. Dynamic organization of microtubules and microtubule organizing centers in Lecudina tuzetae (Gregarina, Apicomplexa). Cell Motility & Cytoskeleton 62:195-209
Omoto, C.K., M. Toso, K. Tang, and L.D. Sibley. 2004 Expressed sequence tag (EST) analysis of Gregarine gametocyst development. Int. J Parasit. 34:1265-1271.
Omoto, C. K., I.R. Gibbons, R. Kamiya, C. Shingyoji, K. Takahashi, G.B. Witman. 1999. Rotation of the central-pair of microtubules in eukaryotic flagella. Mol. Biol. Cell 10: 1-4.
Frey, E., C.J. Brokaw, and C.K. Omoto. 1997. Reactivation at low [ATP] distinguishes among classes of paralyzed flagella mutants. Cell Motil. & Cytosk. 38: 91-99
Omoto, C.K. T. Yagi, E. Kurimoto, and R. Kamiya, 1996. The ability of paralyzed flagella mutants of Chlamydomonas to move. Cell Motil. & Cytosk. 33: 88-94.
Kinoshita, S., T. Miki-Noumura, and C.K. Omoto, 1995. Regulatory role of nucleotides in axonemal function. Cell Motil. & Cytosk. 32: 46-54.