School of Biological Sciences

Mechthild Tegeder


Name: Mechthild Tegeder
Field of Study: Plant Molecular Physiology
Title: Professor
Degrees: Ph.D., Free University of Berlin and University of Göttingen
Office: Abelson 401b
Email: tegeder@wsu.edu
Phone: 509-335-7545
Fax: 509-335-3184
Mailing Address: School of Biological Sciences
Washington State University
PO Box 644236
Pullman WA 99164-4236

Research Interests

Professor Tegeder's research deals with the molecular identification and functional characterization of transport processes controlling the partitioning of organic molecules (e.g. amino acids or ureides) in plants. A major focus is to understand the mechanisms regulating organic nitrogen transfer from the location of production in roots or leaves to sink organs such as developing reproductive structures and seeds. The identification and characterization of transport systems using functional genomic approaches will provide the tools required for biotechnological applications in plants. The ultimate goal is to develop strategies aimed at guaranteeing productivity and improving nutritional quality of important crop plants.

Research areas include:
(a) Organic nitrogen acquisition from the soil;
(b) Mechanisms of assimilate partitioning, particularly amino acids and ureides;
(c) Flower and seed development with respect to nitrogen translocation processes;
(d) Source-sink interaction/phloem transport and regulation of nitrogen partitioning;
(e) Plant-bacteria symbiosis and fixation of atmospheric nitrogen;
(f) Nitrogen transport across subcellular membranes;
(f) Plant metabolism and metabolic network interaction;
(g) Importance of nitrogen partitioning in changing environments (global climate change);
(h) Relevance of nitrogen transport processes for improving plant biomass production and nutritional quality.

Research approaches: Molecular biology, cell biology, biochemistry, physiology.

Representative Publications

Publications since 2011

Tegeder M., Rentsch D. and Patrick J.W. (2011) Organic carbon and nitrogen transporters. In Murphy A., Peer W. and Schulz B., eds, Plant Plasma Membrane: Plant Cell Monographs, Springer, Berlin, pp 331-352.

Tegeder M. and Ward J.M. (2012) Molecular evolution of plant AAP and LHT amino acid transporters, Frontiers in Plant Physiology, 3, 1-11, doi: 10.3389/fpls.2012.00021

Tegeder M. (2012) Transporters for amino acids in plant cells: some functions and many unknowns. Current Opinion in Plant Biology, 15:315-321

Collier R. and Tegeder M. (2012) Soybean ureide transporters play a critical role in nodule development, function and nitrogen export. The Plant Journal 72, 355-367, COVER ILLUSTRATION.

Tegeder M., Ruan Y.-L. and Patrick J.W. (2013) Roles of membrane transporters in phloem functions; in Thompson G. and van Bel A., eds, Biochemistry of Phloem, Wiley-Blackwell, Oxford, pp 63-101.

Publications from 2006 -2010

Tegeder M. and Weber A.P.M. (2006) Metabolite transporters in control of primary plant metabolism. In: Control of primary Metabolism in plants. (Eds) W. C. Plaxton and M. T. McManus. Blackwell Publishing. 85-120.

Pélissier H.C. and Tegeder M. (2007) PvUPS1 plays a role in source-sink transport of allantoin in French bean (Phaseolus vulgaris). Functional Plant Biology, 34, 282-291.

Lee Y.H., Foster J., Chen J., Voll L.M., Weber A.P.M. and Tegeder M. (2007). AAP1 transports uncharged amino acids into roots of Arabidopsis. The Plant Journal, 50, 305-319.

Rentsch D., Schmidt S. and Tegeder M. (2007). Transporters for uptake and allocation of organic nitrogen compounds in plants. FEBS Letters, 581, 2281-2289.

Tegeder M., Tan Q., Grennan A. and Patrick J.W. (2007) Amino acid transporter expression and localisation studies in pea (Pisum sativum L.). Functional Plant Biology, 34, 1019-1028 (month's feature paper).

Tan Q., Grennan A., Rentsch D. and Tegeder M. (2008) Isolation and characterization of an amino acid transporter from French bean (Phaseolus vulgaris L.). Plant Science 174, 348-356.

Foster J., Lee Y.H. and Tegeder M. (2008) Distinct expression of members of the LHT amino acid transporter family in flowers indicates specific roles in plant reproduction. Sex Plant Reprod 21143-152.

Komarova N.Y., Thor K., Gubler A., Meier S., Dietrich D., Weichert A., Suter Grotemeyer M., Tegeder M., and Rentsch D. (2008) AtPTR1 and AtPTR5 transport dipeptides in planta. Plant Physiol 148, 856-869.

Telang M.A., Giri A.P., Pyati P.S., Gupta V.S., Tegeder M. and Franceschi V.R. (2009) Winged bean chymotrypsin inhibitors retard growth of Helicoverpla anmigera. Gene 431, 80-85.

Sanders, A., R. Collier, A. Trethewy, G. Gould, R. Sieker and Tegeder M. (2009) AAP1 regulates import of amino acids into developing Arabidopsis embryos. Plant J 59, 540-552.

Tegeder M. and Rentsch D. (2010) Uptake and Partitioning of Amino Acids and Peptides. Molecular Plant 3, 997-1011.

Tan Q., Zhang L., Grant J., Cooper P. and Tegeder M. (2010) Altered phloem transport of S-methylmethionine affects plant metabolism and seed number in pea plants. Plant Physiology 154, 1886-1896.

Zhang L., Tan Q., Lee R., Trethewy A., Lee Y.-H. and Tegeder M. (2010) Altered amino acids transported by AAP2 changes seed yield and oil content in Arabidopsis. Plant Cell, 22, 3603-3620.

Publications from 2000 - 2005

Tegeder M., Thomas M., Hetherington L., Wang X.-D., Offler C.E. and Patrick J.W. (2000) Genotypic differences in seed growth rates of Phaseolus vulgaris L. Factors contributing to cotyledon sink activity and sink size. Aust J Plant Physiol 27, 119-29.

Tegeder M., Offler C.E., Frommer W.B. and Patrick J.W. (2000) Amino acid transporters are localized to transfer cells of developing pea seeds. Plant Physiol 122, 319-326.

Delrot S., Rochat C., Tegeder M. and Frommer W.B. (2001). Amino acid transport. In: Plant Nitrogen, (Eds) P Lea and JF Morot Gaudry, INRA-Springer, ISBN 3-540-67799-2, pp 213-235.

Rosche E., Blackmore D., Tegeder M., Richardson T., Schroeder H., Higgins T.J.V., Frommer W.B., Offler C.E. and Patrick J.W. (2002) Seed-specific overexpression of a potato sucrose transporter increases sucrose uptake and growth rates of developing pea cotyledons. Plant J 30 (2), 165-175.

Desimone M., Catoni E., Ludewig U., Hilpert M., Schneider A., Kunze R., Tegeder M., Frommer W.B. and Schumacher K. (2002) A novel superfamily of transporters for allantoin and other oxo-derivatives of N heterocyclic compounds in Arabidopsis. Plant Cell 14, 847-56.

Fischer W.N., Loo D.D.F., Koch W., Ludewig U., Boorer K.J., Tegeder M., Rentsch D., Wright E.M. and Frommer W.B. (2002) Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids. Plant J 29, 717-31.

Wipf D., Benjdia M., Tegeder M. and Frommer W.B. (2002). Characterization of a general amino acid permease from Hebeloma cylindrosporum by functional complementation of a yeast mutant. FEBS Letters 528, 119-124.

Wipf D., Ludewig U., Tegeder M., Rentsch D., Koch W. and Frommer W.B. (2002) Amino acid/neurotransmitter transporters are highly conserved between fungi, plants, and animals. Trends Biochem Sci 27, 139-47.

Okumoto S., Schmidt R., Tegeder M., Fischer W.N., Rentsch D, Frommer W.B., Koch W. (2002) High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis. J Biol Chem 277, 45338-45346.

Lalonde S., Tegeder M., Thorne-Holst M., Frommer W.B. and Patrick J.W. (2003) Phloem loading and unloading of sugars and amino acids. Plant Cell Environ 26, 37-56.

Wipf D. , Benjdia M., Rikirsch E., Zimmermann S., Tegeder M., and Frommer W.B. (2003) A Hebeloma cylindrosporum expression cDNA library for suppression cloning in yeast mutants, complementation of a yeast his4 mutant and EST analysis. Genome 46, 177-81.

Koch W., Kwart M., Laubner M. , Heineke D., Stransky H., Frommer W.B. and Tegeder M. (2003) Reduced amino acid content in transgenic potato tubers due to antisense inhibition of the leaf H+/amino acid symporter StAAP1. Plant J 33, 211-220.

Pelissier H. C., Frerich A., Desimone M., Schumacher M., and Tegeder M. (2004) PvUPS1, an allantoin transporter in nodulated roots of French bean. Plant Physiol 134, 664-675.

Okumoto S., Koch W., Tegeder M. Fischer W.N., Biehl A., Leister D., Stierhof Y. and Frommer W.B. (2004) Root phloem-specific expression of the plasma membrane amino acid proton co-transporter AAP3. J Exp Bot, 55: 2155 - 2168.

Lee Y.-H. and Tegeder M. (2004) Selective expression of a novel high affinity transport system for acidic and neutral amino acids in the tapetum cells of Arabidopsis flowers. Plant J, 40, 60-74. COVER ILLUSTRATION.

Publications before 2000

Pickardt T., Schieder O., Saalbach I., Tegeder M., Machemahl F., Saalbach G., Kohn H. and Muentz K. (1994). Regeneration and transformation in the legume Vicia narbonensis. In: Oono K. (ed.). Plant Tissue and Gene Manipulation for Breeding and Formation of Phytochemicals. NIAR, Japan, pp 89-94.

Tegeder M., Gebhardt D., Schieder O. and Pickardt T. (1995). Thidiazuron-induced plant regeneration from protoplasts of Vicia faba cv. Mythos. Plant Cell Rep 15, 164-169.

Tegeder M., Schieder O. and Pickardt T. (1995). Breakthrough in the plant regeneration from protoplasts of Vicia faba and V. narbonensis. Current Issues in Plant and Cellullar Biology. Kluwer, London, pp 75-80.

Tegeder M., Kohn H., Nibbe M., Schieder O. and Pickardt T. (1996). Plant regeneration from protoplasts of Vicia narbonensis via somatic embryogenesis and shoot organogenesis. Plant Cell Rep 16, 22-25.

Zenkteler M., Tegeder M., and Schieder O. (1998). Embryological studies of reciprocal crosses between Vicia faba and Vicia narbonensis. Acta Soc Bot Pol 67, 37-43.

Ward J.M., Kühn C., Tegeder M., and Frommer W.B. (1997). Sucrose transport in plants. International Review of Cytology 178, 41-71.

Harrington G.N., Nussbaumer Y., Wang X.-D. Tegeder M., Offler C.E, Patrick J.W., Franceschi V.R. and Frommer W.B. (1997). Temporal and spatial expression of plasma membrane sucrose transport-related genes in cotyledons of Vicia faba L. Protoplasma 200, 35-50.

Harrington G.N., Franceschi V.R., Offler C.E., Patrick J.W., Tegeder M., Frommer W.B., Harper J.F. and Hitz W.D. (1997). Cell specific expression of three genes involved in plasma membrane sucrose transport in developing Vicia faba seed. Protoplasma 197, 160-173.

Fischer W.-N., André B.A., Rentsch D., Krolkiewicz S., Tegeder M., Breitkreuz K. and Frommer W.B. (1998). Amino acid transport in plants. Trends Biochem Sci 3, 188-95.

Montamat F., Tegeder M., Frommer W.B. and Delrot S. (1999) Cloning and expression of a pod-specific amino acid transporter from broad bean. Plant Mol Biol 41, 259-268.

Tegeder M., Wang X.-D, Frommer W.B, Offler C.E, and Patrick J.W. (1999). Sucrose transport into developing seeds of Pisum sativum L. Plant J 18, 151-61.

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