School of Biological Sciences

Michelle [Shelley] McGuire


Name: Michelle [Shelley] McGuire
Field of Study: Lactation Physiology / Nutrition
Title: Associate Professor
Degrees: Ph.D., Human Nutrition, Cornell University
Office: 375 Eastlick
Email: smcguire@wsu.edu
Phone: 335-3896
Mailing Address: School of Biological Sciences
PO Box 644236
Pullman, WA 99164-4236

Research Interests

Shelley McGuire received her BS in biology from the University of Illinois (1986), an MS in nutritional sciences from the University of Illinois (1988), and a PhD in human nutrition from Cornell University (1994). Her research focuses primarily on understanding better how maternal dietary intake and nutritional status influence breast health, milk composition, and duration of postpartum amenorrhea.

Human Milk and Lactation Research   Of particular interest to her research is understanding the importance of dietary lipids to maternal and infant health. In this regard, her research group has conducted several clinical trials designed to examine the effects of trans fatty acids and conjugated linoleic acids (CLA) on milk production and fatty acid concentrations. These studies have provided important evidence that maternal trans fatty acid consumption can decrease total milk fat, especially in lean women. This interactive effect is likely mediated by the inability of lean (but not heavier) women consuming trans fatty acids to mobilize sufficient adipose stores. In addition, her research has shown that maternal consumption of some, but not all, forms of CLA results in milk fat depression. This finding is especially important, as CLA supplements are commercially available and marketed to people trying to lose weight (a situation commonly encountered by postpartum women) and has impacted the ability of food manufacturers to add these CLA isomers to the food system. Shelley also has a long-standing interest in understanding the physiologic mechanisms driving the return of ovulatory function during the postpartum period. Her work has shown a previously undescribed interactive relationship among body fat changes, activity levels, and duration of postpartum amenorrhea. More recently, Shelley and her husband Dr. Mark McGuire (at the University of Idaho) have become interested in the presence of commensal and pathogenic bacteria in the human breast and the possibility that maternal fatty acid intake might alter the metabolism of these organisms and/or their impact on mammary health. As an extension, they are interested in how this might impact short- and long-term infant health. This area of research has direct implications in terms of milk production, infant health, mastitis, breast cancer, and other breast-related health issues.

Science Writing and Nutrition Translation   Dr. McGuire is also passionately committed to bettering human health through the provision of user-friendly, high-quality, evidence-based nutrition information. Shelley is a seasoned science writer, having coauthored an introductory textbook now in its second edition (Nutritional Sciences: from Fundamentals to Food, Brooks Cole) as well as numerous other nutrition-related articles for both nutrition-savvy and general audiences. Currently, she consults as a technical writer for several private and federal agencies. She also researches and writes monthly press releases highlighting the “editors’ picks” from The Journal of Nutrition and The American Journal of Clinical Nutrition, the world’s most prestigious peer-reviewed nutrition journals.

Public Intellect and Professional Service   Shelley is actively involved in several professional organizations on both national and international levels, having been a member of the American Society for Nutrition (ASN) since 1987, and served on its executive board from 2006-2008. Shelley was named a National Spokesperson for ASN in 2008 and enjoys the challenge of frequent interviews with the media such as the LA Times, Glamour Magazine, Redbook, Travel and Leisure, and various radio broadcasts. Shelley is also a member of the International Society for Research in Human Milk and Lactation (ISRHML), having received its Ehrlich-Koldovsky Award to “recognize a young investigator who has begun to make outstanding, original scientific contributions to the study of human milk and lactation” in 2002. She is currently the secretary/treasurer of this Society.

Representative Publications

Ritzenthaler KL, McGuire MK, McGuire MA, Shahin AM, Shultz T, Dasgupta N. 2012 Conjugated linoleic acid (CLA) in human plasma and lipid fractions and their relations with CLA intake. J Nutr, in press.

Hunt K, Preuss J, Nissan C, Davlin C, Williams J, Shafii B, Richardson A, McGuire M, Bode L, & McGuire M. (2012) Human milk oligosaccharides promote the growth of staphylococci. Appl Environ Micro May 2012, doi: 10.1128/​AEM.00477-12.

Hunt KM, Williams JE, Shafii B, Hunt MK, Behre R, Ting R, McGuire MK, & McGuire MA. (2012) Mastitis increases free fatty acids and markers of inflammation in human milk. J Breastfeed Med May 2012, doi:10.1089/bfm.2011.0141.

Hunt KM, Foster JA, Forney LJ, Schütte UME, Beck DL, McGuire MK, & McGuire MA. (2011) Characterization of the diversity and temporal stability of bacterial communities in human milk. PLoS ONE 6(6): e21313. doi:10.1371/journal.pone.0021313

Nudda A, McGuire MK, Battacone G, & Pulina G. (2011) Documentation of fatty acid profiles in lamb meat and lamb-based infant foods. J Food Sci. 76:H43-7.

Picciano MF, Yetley EA, Coates PM, & McGuire MK. (2009) Update on folate and human health. (invited review) Nutrition Today. 44:142-152.

Picciano MF, McGuire MK. (2009) Use of dietary supplements by pregnant and lactating women in North America. Am J Clin Nutr ;89:663S-7S.

Ryan-Borchers T, Park JS, Chew BP, Beerman KA & McGuire MK. (2008) Soy isoflavones modulate do not influence thyroid function in healthy postmenopausal women. Topics Clin Nutr 23:13-22.

Hasin A, Griinari M., Shahin AM, Williams J, McGuire MA & McGuire MK. (2007) Consumption of c9,t11-18:2 or t10,c12-18:2 enriched dietary supplements does not influence milk macronutrients in healthy, lactating women. Lipids 42:835-43.

Mosley SA, Shahin AM, Williams JE, McGuire MA, & McGuire MK. (2007) Supplemental conjugated linoleic acid (CLA) consumption does not influence milk macronutrient contents in all healthy lactating women. Lipids 42:723-729.

Fournier LR, Ryan-Borchers TA, Robison LM, Weidiger M, Park J-S, Chew BP, McGuire MK, Sclar DA, Skaer TL, & Beerman KA. (2007) The effects of soy milk and soy isoflavone supplements on cognitive performance in healthy, postmenopausal women. J Nutr, Health, Aging 11:155-64.

Ryan-Borchers TA, Park JS, Chew BP, McGuire MK, Fournier LR & Beerman KA. (2006) Soy isoflavones modulate immune function in healthy postmenopausal women. Am J Clin Nutr 83:1118-25.

Mosley EE, McGuire MK, Williams JE & McGuire MA. (2006) Cis-9, trans-11 conjugated linoleic acid is synthesized from vaccenic acid in lactating women. J Nutr 136:2297-301, 2006.

Shahin AM, McGuire MK, Anderson N, Williams J. & McGuire MA. (2006) Effects of margarine and butter consumption on distribution of trans-18:1 fatty acid isomers and conjugated linoleic acid in major serum lipid classes in lactating women. Lipids 41:141-47.

Mosley EE, Wright A, McGuire MK & McGuire MA. (2005) Trans fatty acid concentration of milk produced by women in the United States. Am J Clin Nutr 82:1292-1297.

Anderson NK, Beerman KA, McGuire MA, Dasgupta N, Griinari MJ, Williams J & McGuire MK. (2005) Type of dietary fat influences total milk fat content in lean women J Nutr 135:416-421.

Ritzenthaler KL, McGuire MK, McGuire MA, Shultz TD, Koepp AE, Leudecke LO, Hanson, TW, Chew BP &  Dasgupta N. (2005) Consumption of conjugated linoleic acid (CLA) from CLA-enriched cheese does not alter milk fat or immunity in lactating women. J Nutr 135:422-430.

McCann SE, Ip C, Ip MM, McGuire MK, Muti P, Edge SE, Trevisan M & Freudenheim JL. (2004) Dietary intake of conjugated linoleic acids and risk of pre- and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study). Cancer Epidemiol Biomarkers Prev 9:1480 1484

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